INDICATIONS AND USAGE:
Gram-positive Organisms.
Streptococcus pneumoniae,
Streptococcus pyogenes.
Gram-negative Organisms.
Haemophilus influenzae
(beta-lactamase positive and negative strains),
Moraxella (Branhamella) catarrhalis
(most of which are beta-lactamase positive),
Escherichia coli,
Proteus mirabilis,
Neisseria gonorrhoeae
(including penicillinase- and non-penicillinase-producing strains).
Cefixime has been shown to be active in vitro against most strains of the following organisms;
however, clinical efficacy has not been established.
Gram-positive Organisms.
Streptococcus agalactiae .
Gram-negative Organisms.
Haemophilus parainfluenzae
(beta-lactamase positive and negative strains),
Proteus vulgaris,
Klebsiella pneumoniae,
Klebsiella oxytoca,
Pasteurella multocida,
Providencia species,
Salmonella species,
Shigella species,
Citrobacter amalonaticus,
Citrobacter diversus,
Serratia marcescens.
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Note: Pseudomonas species, strains of group D streptococci (including enterococci), Listeria
monocytogenes, most strains of staphylococci (including methicillin-resistant strains) and
most strains of Enterobacter are resistant to cefixime. In addition, most strains of Bacteroides
fragilis and Clostridia are resistant to cefixime.

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